Best New Clubs in Mayfair: Where to Go in 2026
Mayfair's nightlife scene has fresh blood. Here are the newest clubs worth your time in 2026, plus the established venues that refuse to be outshone.
Mayfair Never Stands Still
The thing about Mayfair is that competition never stops. New venues open, old ones close, and the ones that survive do so because they're genuinely excellent. 2026 has brought some serious new contenders to the scene, and forced the established names to step up.
Here's what's new, what's evolved, and where you should be going right now.
The New Wave
Itzel, Rumour and 99 Regent Street
Three familiar Mayfair addresses have new names over the door. Itzel has opened at 15 Berkeley Street, the former home of Funky Buddha, and runs Thursday to Saturday. Rumour has taken over the old Tabu space at 1 Dover Street: one intimate room of red velvet booths with a no-photography policy, playing open-format hip hop, RnB and house. 99 Regent Street has replaced Cuckoo Club, with hip hop and RnB upstairs and house downstairs. Both open Wednesday to Saturday from 11pm to 4am, and we book tables and guestlist at both. Itzel's programming is still settling, so message us before you go and we will tell you what it is playing that week.
Best for: People who want to try the newest rooms in the area.
Selene London
Selene London, just north of Oxford Circus in Fitzrovia, opened in the former Libertine space and is open Thursday to Sunday. Selene is elegant and refined. The Greek goddess-inspired design is subtle and beautiful: golds, creams, and deep midnight tones throughout.
The standout here is the cocktail programme. Selene takes its drinks seriously, and it shows. The music leans house and commercial, building from ambient to full dance floor energy as the night progresses. It's attracted a slightly more mature, sophisticated crowd: people who want quality over chaos.
Best for: Date nights, cocktail lovers, and anyone who prefers elegance over intensity.
Read our full Selene London guide.
The Established Names Still Delivering
New doesn't automatically mean better. Several Mayfair veterans have adapted and evolved, and they're still among the best nights out in the area.
The Box
The Box continues to be London's most provocative nightclub. The theatrical performances, boundary-pushing acts, and fashion-forward crowd make it unlike anything else in the city. No other venue delivers the same combination of nightlife and live theatre.
The Box doesn't need to reinvent itself because nothing else has come close to replicating what it does. It remains one of the most unique nights out in London, full stop.
Read our full The Box guide.
Reign London
Reign London has continued to raise its production value. The aerial acts, live singers, and choreographed performances remain the best in Mayfair. If you want your night to feel like an event, something beyond just music and drinks, Reign is still the top pick.
Read our full Reign London guide.
Quick Comparison
| Venue | Style | Music | Best Night | Opened |
|---|---|---|---|---|
| Selene London | Elegant & refined | House, Commercial | Friday | New |
| The Box | Theatrical & provocative | Mixed | Saturday | Established |
| Reign London | Showclub & extravagant | Commercial, House, Hip-Hop | Saturday | Established |
How to Choose
If you want the newest experience, hit Selene London, Rumour or 99 Regent Street, or ask us about Itzel.
If you want proven quality, Reign London delivers every time.
If you want something genuinely different, The Box is in a category of its own.
And if you still can't decide, check our best clubs in Mayfair ranking for the full picture, or read our guides to the best Thursday nights and Saturday nights in London.
Not sure where to go tonight? Message us on WhatsApp: tell us your vibe and we'll point you in the right direction.